Prednisolone

Prednisolone Uses

Uses Dosage Side effects Pregnancy OverdoseActions

What is Prednisolone?

Prednisolone 0.12% (Pred Mild®) eye drops is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns.

Prednisolone 1% (Pred Forte®) eye drops is used to treat inflammation of the eyes caused by certain conditions.

Prednisolone is a steroid medicine that is used to relieve the redness, itching, and swelling caused by eye infections and other conditions.

Prednisolone 0.12% and 1% are available only with your doctor’s prescription.

Prednisolone indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician. sponsored

Prednisolone (Prednisolone (syrup)) Syrup is indicated in the following conditions:

1. Endocrine Disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice: synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralo-corticoid supplementation is of particular importance).

2. Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

9. Neoplastic Diseases: For palliative management of:

10. Edematous States: To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.

11. Gastrointestinal Diseases: To tide the patient over a critical period of the disease in:

12. Miscellaneous: Tuberculous meningitis with subarachnoid block or impending block used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement.

In addition to the above indications Prednisolone (Prednisolone (syrup)) Syrup is indicated for systemic dermatomyositis (polymyositis).

How should I use Prednisolone?

Use Prednisolone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Prednisolone by mouth with food.
  • Swallow Prednisolone whole. Do not break, crush, or chew before swallowing. Do not use partial tablets.
  • Do not remove the blister from the outer pouch until you are ready to take Prednisolone. Make sure that your hands are dry when you open the blister pack. Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. The medicine may be taken with or without water. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use.
  • If you miss a dose of Prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone.

Uses of Prednisolone in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it. sponsored

This medication is used to treat certain eye conditions due to inflammation or injury. Prednisolone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.

How to use Prednisolone ophthalmic

Unless otherwise directed by your doctor, do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to the manufacturer’s directions, and check with your doctor before you begin using them again.

If your doctor does approve the wearing of contact lenses during treatment with this medication, remove the lenses before using the eye drops. The preservative in this product may be absorbed by contact lenses. Wait at least 15 minutes after each dose of the eye drop before wearing the lenses again.

To apply eye drops, wash your hands first. If you are using a suspension form of this medication, shake the bottle well before using. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed and if your dose is for more than 1 drop.

Apply as often as directed by your doctor. Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (for example, other drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

The dosage and length of treatment are based on your medical condition and response to treatment. Do not use this medication more often or for longer than prescribed because doing so may increase your risk of side effects.

Continue to use this medication for the full time prescribed. Do not stop using this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

Do not use this product if it becomes contaminated (for example, drops turn a dark color). Use of contaminated eye medication can cause infection, serious damage to the eye, and loss of vision. Contact your doctor or pharmacist for more information.

Tell your doctor if your condition does not improve after 2 days or if it worsens.

Prednisolone description

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to Prednisolone in the liver.

Prednisolone dosage

Recommended Dosing

Dosage of Prednisolone (Prednisolone sodium phosphate) should be individualized according to the severity of the disease and the response of the patient. For pediatric patients, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight.

Do not break or use partial Prednisolone (Prednisolone sodium phosphate) tablets. Use an appropriate formulation of Prednisolone if indicated dose cannot be obtained using Prednisolone. This may become important in the treatment of conditions that require tapering doses that cannot be adequately accommodated by Prednisolone (Prednisolone sodium phosphate), e.g., tapering the dose below 10 mg.

The initial dose of Prednisolone (Prednisolone sodium phosphate) may vary from 10 to 60 mg (Prednisolone base) per day, depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time, there is a lack of satisfactory clinical response, Prednisolone should be discontinued and the patient placed on other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage that will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient’s individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of Prednisolone (Prednisolone sodium phosphate) for a period of time consistent with the patient’s condition. If after long term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.

Prednisolone (Prednisolone sodium phosphate) are packaged in a blister. Patients should be instructed not to remove the tablet from the blister until just prior to dosing. The blister pack should then be peeled open, and the orally disintegrating tablet placed on the tongue, where tablets may be swallowed whole as any conventional tablet, or allowed to dissolve in the mouth, with or without the assistance of water.

Orally disintegrating tablet dosage forms are friable and are not intended to be cut, split, or broken.Multiple Sclerosis

In the treatment of acute exacerbations of multiple sclerosis, daily doses of 200 mg of Prednisolone for a week followed by 80 mg every other day for one month have been shown to be effective.Pediatric

In pediatric patients, the initial dose of Prednisolone may vary depending on the specific disease entity being treated. The range of initial doses is 0.14 to 2 mg/kg/day in three or four divided doses (4 to 60 mg/m/day.Asthma

The National Heart, Lung, and Blood Institute (NHLBI) recommended dosing for systemic prednisone, Prednisolone or methylprednisolone in children whose asthma is uncontrolled by inhaled corricosteroids and long-acting bronchodilators is 1-2 mg/kg/day in single or divided doses.

It is further recommended that short course, or “burst” therapy, be continued until a child achieves a peak expiratory flow rate of 80% of his or her personal best or symptoms resolve. This usually requires 3 to 10 days of treatment, although it can take longer. There is no evidence that tapering the dose after improvement will prevent a relapse.Recommended Monitoring

Blood pressure, body weight, routine laboratory studies, including serum potassium and fasting blood glucose, should be obtained at regular intervals during prolonged therapy. Appropriate diagnostic studies should be performed in patients with known or suspected peptic ulcer disease and in patients at risk for reactivation of latent tuberculosis infections.Corticosteroid Comparison Chart

For the purpose of comparison, one 10 mg Prednisolone tablet (13.4 mg Prednisolone sodium phosphate) is equivalent to the following milligram dosage of the various glucocorricoids: Betamethasone 1.75 mg

  • 10 mg Prednisolone (as 13.4 mg Prednisolone sodium phosphate)
  • 15 mg Prednisolone (as 20.2 mg Prednisolone sodium phosphate)
  • 30 mg Prednisolone (as 40.3 mg Prednisolone sodium phosphate)

Prednisolone (Prednisolone sodium phosphate orally disintegrating tablets) 13.4 mg Prednisolone sodium phosphate (equivalent to 10 mg Prednisolone base) are white, flat faced, bevelled tablet, debossed with ORA on one side and 10 on the other. Supplied as:

  • NDC 59630-700-48: 48 tablets per carton. Each carton has 8 cards containing 6 tablets.

Prednisolone (Prednisolone sodium phosphate orally disintegrating tablets) 20.2 mg Prednisolone sodium phosphate (equivalent to 15 mg Prednisolone base) are white, flat faced, bevelled tablet, debossed with ORA on one side and 15 on the other. Supplied as:

  • NDC 59630-701-48: 48 tablets per carton. Each carton has 8 cards containing 6 tablets.

Prednisolone: (Prednisolone sodium phosphate orally disintegrating tablets) 40.3 mg Prednisolone sodium phosphate (equivalent to 30 mg Prednisolone base) are white, flat faced, beveled tablets, debossed with ORA on one side and 30 on the other. Supplied as:

  • NDC 59630-702-48: 48 tablets per carton. Each carton has 8 cards containing 6 tablets.

Store at 20 to 25°C (68 to 77°F); excursions permitted to 15 to 30°C (59 to 86°F).. Protect from moisture.

Do not break or use partial Prednisolone (Prednisolone sodium phosphate) tablets. Keep out of the reach of children.

Manufactured for: Shionogi Pharma, Inc. Atlanta, GA 30328. Manufactured by: CIMA® LABS INC., Eden Prairie, MN 55344. Revised 07/2010

Prednisolone interactions

May lead to loss of Prednisolone-induced adrenal suppression.

Amphotericin B

Coadministration may be followed by cardiac enlargement and CHF.

Anticholinesterase agents

Coadministration may produce severe weakness in patients with myasthenia gravis. If possible, withdraw anticholinesterase agent 24 h prior to starting Prednisolone.

Antidiabetic agents

Because Prednisolone may increase blood glucose concentrations, dose adjustments of antidiabetic agents may be required.

Aspirin and other salicylates, NSAIDs

Risk of GI bleeding may be increased. Salicylate clearance may be increased.

CYP3A4 inducers (eg, barbiturates, carbamazepine, phenytoin, rifampin)

Prednisolone metabolism may be increased, reducing Prednisolone plasma levels and necessitating an increase in dosage.

CYP3A4 inhibitors (eg, estrogens [eg, hormonal contraceptives], ketoconazole, macrolide antibiotics [eg, erythromycin])

Prednisolone metabolism may be decreased, increasing Prednisolone plasma levels and increasing the risk of adverse reactions.

Cholestyramine

Prednisolone clearance may be increased, reducing plasma levels and decreasing the efficacy.

Cyclosporine

Increased activity of cyclosporine and Prednisolone may occur. Convulsions have been reported with coadministration of corticosteroids and cyclosporine.

Digitalis glycosides

Because of possible hypokalemia, the risk of arrhythmias may be increased.

Isoniazid

Isoniazid serum levels may be reduced, decreasing the efficacy.

Potassium-depleting agents (eg, amphotericin B, diuretics)

Risk of hypokalemia may be increased.

Toxoids and live or inactivated vaccines

Because of inhibition of antibody response, patients on prolonged Prednisolone therapy may exhibit a diminished response to toxoids and live or inactivated vaccines. Replication of some organisms contained in live attenuated vaccines may be potentiated.

Warfarin

Because data are conflicting, monitor coagulation indices frequently.

Prednisolone side effects

What are the possible side effects of Prednisolone?

Applies to Prednisolone: oral liquid, oral solution, oral suspension, oral syrup, oral tablet, oral tablet disintegrating

As well as its needed effects, Prednisolone (the active ingredient contained in Prednisolone) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Prednisolone, check with your doctor immediately:

More common:

  • reddish purple lines on the arms, face, legs, trunk, or groin
  • swelling of the stomach area
  • thinning of the scalp hair

Prednisolone contraindications

What is the most important information I should know about Prednisolone?

You should not use this medication if you are allergic to Prednisolone, or if you have a fungal infection anywhere in your body.

Before taking Prednisolone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a “live” vaccine while using Prednisolone. The vaccine may not work as well during this time, and may not fully protect you from disease.

Do not stop using Prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using Prednisolone.

Wear a medical alert tag or carry an ID card stating that you take Prednisolone. Any medical care provider who treats you should know that you take steroid medication.

Active ingredient matches for Prednisolone:

Prednisolone1 consumer reported useful Was the Prednisolone drug useful in terms of decreasing the symptom or the disease?According to the reports released by pharmaoffshore.co website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug. UsersReport useful »1 consumer reported price estimates Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by pharmaoffshore.co website users about whether the Prednisolone drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost. UsersReport price estimates »2 consumers reported time for results To what extent do I have to use Prednisolone before I begin to see changes in my health conditions?As part of the reports released by pharmaoffshore.co website users, it takes 2 weeks and a few days before you notice an improvement in your health conditions.Please note, it doesn’t mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Prednisolone. To get the time effectiveness of using Prednisolone drug by other patients

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