Sildigra (Sildenafil) 25 mg – 200 mg shipped from UK
Generic Name: Sildenafil
Manufacturer: Centurion Lab
Sildenafil can treat erectile dysfunction. It can also treat high blood pressure in the lungs (pulmonary arterial hypertension).
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Generic Viagra Sildigra
Generic Viagra comes in multiple strengths.
Generic Viagra, generic (Viagra-equivalent) Sildigra is sold in tablets of 25 mg, 50 mg, 100 mg, 150 mg and 200 mg.
Viagra and its generic, Sildigra, are the most popular drugs on the market today.
What Is Sildigra?
Sildigra is used to treat men who have erectile dysfunction (also called sexual impotence). Sildigra belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.
Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body’s normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, Sildigra helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, Sildigra will not work to cause an erection.
Sildigra is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Sildigra works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart.
Sildigra is available only with your doctor’s prescription.
Sildigra is indicated for the treatment of pulmonary arterial hypertension (WHO Group I) in adults to improve exercise ability and delay clinical worsening. The delay in clinical worsening was demonstrated when Sildigra was added to background epoprostenol therapy.
Studies establishing effectiveness were short-term (12 to 16 weeks), and included predominately patients with New York Heart Association (NYHA) Functional Class II-III symptoms and idiopathic etiology (71%) or associated with connective tissue disease (CTD) (25%).
Limitation of Use: Adding Sildigra to bosentan therapy does not result in any beneficial effect on exercise capacity.
How should I use Sildigra?
Use Sildigra suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet with detailed instructions for use is available with Sildigra suspension. Talk to your pharmacist if you have questions about this information.
- Take Sildigra suspension by mouth with or without food. Take your doses 4 to 6 hours apart unless your doctor tells you otherwise.
- Shake well for at least 10 seconds before each use.
- Use the oral dosing syringe that comes with Sildigra suspension to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Do not mix Sildigra suspension with other medicine or flavoring.
- Wash and dry the dosing syringe after each use.
- Take Sildigra suspension on a regular schedule to get the most benefit from it. Take it at the same time each day.
- Continue to take Sildigra suspension even if you feel well. Do not miss any doses.
- Do not suddenly stop taking Sildigra suspension or change your dose without talking to your doctor.
- If you miss a dose of Sildigra suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Sildigra suspension.
Uses of Sildigra in details
Use: Labeled Indications
Erectile dysfunction: Sildigra: Treatment of erectile dysfunction.
Pulmonary arterial hypertension: Sildigra: Treatment of pulmonary arterial hypertension (WHO Group I; efficacy established predominately in patients with WHO/NYHA functional class II and III) in adults to improve exercise ability and delay clinical worsening.
Off Label Uses
High-altitude pulmonary edema
Based on the 2019 Wilderness Medical Society consensus guidelines for the prevention and treatment of acute altitude illness, Sildigra is a recommended option for the prevention and treatment of high-altitude pulmonary edema (as an adjunct to descent, oxygen, or portable hyperbaric therapy). Supplemental oxygen and descent are the mainstays of treatment. For prevention, Sildigra should only be considered for patients with a history of high-altitude pulmonary edema, especially multiple episodes.
Data from a meta-analysis and small controlled trials support the use of Sildigra for the Raynaud phenomenon related to systemic sclerosis, demonstrating a decrease in the frequency and severity of attacks.
Each film-coated tablet contains Sildigra citrate equivalent to 50 mg Sildigra.
Each film-coated tablet contains Sildigra citrate equivalent to 100 mg Sildigra.
Each orodispersible tablet contains Sildigra citrate equivalent to 50 mg Sildigra.
Excipients/Inactive Ingredients: Film-Coated Tablets: In addition to the active ingredient, Sildigra citrate, each tablet contains the following inactive ingredients: Microcrystalline cellulose, calcium hydrogen phosphate (anhydrous), croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose (hypromellose), titanium dioxide (E171), lactose, triacetin, and FD & C Blue #2 aluminum lake [indigo carmine aluminum lake (E132)].
Orodispersible Tablets: In addition to the active ingredient, Sildigra citrate, each orodispersible tablet contains the following inactive ingredients: Microcrystalline cellulose, silica hydrophobic colloidal, croscarmellose sodium, magnesium stearate, indigo carmine aluminum lake (E132), sucralose, mannitol, crospovidone, polyvinyl acetate, povidone, flavoring (contains: Maltodextrin and dextrin), natural flavoring (contains: Maltodextrin, E422 glycerol and E1520 propylene glycol), lemon flavoring (contains: Maltodextrin and E307 alpha-tocopherol).
Sildigra Tablets AndOral Suspension
The recommended dose of Sildigra is 5 mg or 20 mg three times a day. Administer Sildigra doses of 4-6 hours apart.
In the clinical trial, no greater efficacy was achieved with the use of higher doses. Treatment with doses higher than 20 mg three times a day is not recommended.
Sildigra injection is for the continued treatment of patients with PAH who are currently prescribed oral Sildigra and who are temporarily unable to take oral medication.
The recommended dose is 2.5 mg or 10 mg administered as an intravenous bolus injection three times a day. The dose of Sildigra injection does not need to be adjusted for body weight.
A 10 mg dose of Sildigra injection is predicted to provide the pharmacological effect of Sildigra and its N-desmethyl metabolite equivalent to that of a 20 mg oral dose.
Reconstitution Of The Powder ForOral Suspension
- Tap the bottle to release the powder.
- Remove the cap.
- Accurately measure out 60 mL of water and pour the water into the bottle. (Figure 1)
- Replace the cap and shake the bottle vigorously for a minimum of 30 seconds. (Figure 2)
- Remove the cap.
- Accurately measure out another 30 mL of water and add this to the bottle. You should always add a total of 90 mL of water irrespective of the dose prescribed. (Figure 3)
- Replace the cap and shake the bottle vigorously for a minimum of 30 seconds. (Figure 4)
- Remove the cap.
- Press the bottle adaptor into the neck of the bottle (as shown on Figure 5, below). The adaptor is provided so that you can fill the oral syringe with medicine from the bottle. Replace the cap on the bottle.
- Write the expiration date of the constituted oral suspension on the bottle label (the expiration date of the constituted oral suspension is 60 days from the date of the constitution).
Do not mix with any other medication or additional flavoring agent.
Dosage Forms And Strengths Sildigra Tablets
White, film-coated, round tablets engraved with “RVT20” containing Sildigra citrate equivalent to 20 mg of Sildigra.
A single-use vial containing 10 mg/12.5 mL of Sildigra.
Sildigra for Oral Suspension
White to off-white powders containing 1.57 g of Sildigra citrate (equivalent to 1.12 g of Sildigra) in a bottle intended for the constitution. The following constitution with 90 mL of water, the volume of the oral suspension is 112 mL and the oral suspension contains 10 mg/mL Sildigra. A 2 mL oral syringe (with 0.5 mL and 2 mL dose markings) and a press-in bottle adaptor are also provided.
Storage And Handling
Sildigra tablets are supplied as white, film-coated, round tablets containing Sildigra citrate equivalent to the nominally indicated amount of Sildigra as follows:
Sildigra TabletsVial individually packaged in a carton 10 mg /12.5 mL 0069-0338-01
Recommended Storage for Sildigra Injection: Store at controlled room temperature 20°C – 25°C (68°F -77°F); excursions permitted to 15°C – 30°C (59°F – 86°F).
Sildigra powder for oral suspension is supplied in amber glass bottles. Each bottle contains white to off-white powders containing 1.57 g of Sildigra citrate (equivalent to 1.12 g Sildigra). Following the constitution, the volume of the oral suspension is 112 mL (10 mg Sildigra/mL). A 2 mL oral dosing syringe (with 0.5 mL and 2 mL dose markings) and a press-in bottle adaptor are also provided.
Sildigra Powder forPowder for oral suspension – bottle 10 mg/mL (when reconstituted) 0069-0336-21
Recommended storage for Sildigra for oral suspension: Store below 30°C (86°F) in the original package in order to protect from moisture.
Store below 30°C (86°F) or in the refrigerator at 2°C to 8°C (36° F – 46°F). Do not freeze. The shelf-life of the constituted oral suspension is 60 days. Any remaining oral suspension should be discarded 60 days after the constitution.
Distributed by: Pfizer Labs, Division of Pfizer Inc., NY, NY 10017. Revised: Apr 2015
Effects of Other Drugs on Sildigra Sildigra Citrate
In Vitro Studies: Sildigra Sildigra metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route). Therefore, inhibitors of these isoenzymes may reduce Sildigra clearance.
In Vivo Studies: Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma Sildigra concentrations when coadministered with Sildigra citrate (50 mg) to healthy volunteers.
When a single 100 mg dose of Sildigra citrate was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in Sildigra systemic exposure (AUC). In addition, coadministration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with Sildigra citrate (100 mg single dose) resulted in a 140% increase in Sildigra Cmax and a 210% increase in Sildigra AUC. Sildigra citrate had no effect on saquinavir pharmacokinetics. Stronger CYP3A4 inhibitors such as ketoconazole or itraconazole would be expected to have still greater effects, and population data from patients in clinical trials did indicate a reduction in Sildigra clearance when it was coadministered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine).
Coadministration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (400 mg bid) with Sildigra citrate (100 mg single dose) resulted in a 300% (4-fold) increase in Sildigra Cmax and a 1000% (11-fold) increase in Sildigra plasma AUC. At 24 hours the plasma levels of Sildigra were still approximately 200 ng/mL, compared to approximately 5 ng/mL when Sildigra was dosed alone. This is consistent with ritonavir’s marked effects on a broad range of P450 substrates. Sildigra citrate had no effect on ritonavir pharmacokinetics.
It can be expected that the concomitant administration of CYP3A4 inducers, such as rifampin, will decrease plasma levels of Sildigra.
Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of Sildigra citrate.
Pharmacokinetic data from patients in clinical trials showed no effect on Sildigra pharmacokinetics of CYP2C9 inhibitors (such as tolbutamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The AUC of the active metabolite, N-desmethyl Sildigra, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence.
Effects of Sildigra Citrate on Other Drugs
In Vitro Studies: Sildigra Sildigra is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 mM). Given Sildigra’s peak plasma concentrations of approximately 1 mcM after recommended doses, it is unlikely that Sildigra citrate will alter the clearance of substrates of these isoenzymes.
In Vivo Studies: When Sildigra citrate 100 mg oral was coadministered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic.
No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9.
Sildigra citrate (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg).
Sildigra citrate (50 mg) did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08%.
Sildigra (100 mg) did not affect the steady-state pharmacokinetics of the HIV protease inhibitors, saquinavir, and ritonavir, both of which are CYP3A4 substrates.
Viagra Sildigra side effects
- Vaso-occlusive crisis
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Safety data of Sildigra in adults were obtained from the 12-week, placebo-controlled clinical study (Study 1) and an open-label extension study in 277 Sildigra-treated patients with PAH, WHO Group I.
The overall frequency of discontinuation in Sildigra-treated patients on 20 mg three times a day was 3% and was the same for the placebo group.
In Study 1, the adverse reactions that were reported by at least 3% of Sildigra-treated patients (20 mg three times a day) and were more frequent in Sildigra-treated patients than in placebo-treated patients are shown in Table 1. Adverse reactions were generally transient and mild to moderate in nature.
Table 1: Most Common Adverse Reactions in Patients with PAH in Study 1 (More Frequent in Sildigra-Treated Patients than Placebo-Treated Patients and Incidence ≥ 3% in Sildigra-Treated Patients)
Placebo, %3 3
At doses higher than the recommended 20 mg three times a day, there was a greater incidence of some adverse reactions including flushing, diarrhea, myalgia and visual disturbances. Visual disturbances were identified as mild and transient, and were predominately color-tinge to vision, but also increased sensitivity to light or blurred vision.
The incidence of retinal hemorrhage with Sildigra 20 mg three times a day was 1.4% versus 0% placebo and for all Sildigra doses studied was 1.9% versus 0% placebo. The incidence of eye hemorrhage at both 20 mg three times a day and at all doses studied was 1.4% for Sildigra versus 1.4% for placebo. The patients experiencing these reactions had risk factors for hemorrhage including concurrent anticoagulant therapy.
In a placebo-controlled fixed dose titration study (Study 2) of Sildigra (starting with recommended dose of 20 mg and increased to 40 mg and then 80 mg all three times a day) as an adjunct to intravenous epoprostenol in patients with PAH, the adverse reactions that were more frequent in the Sildigra + epoprostenol group than in the epoprostenol group (greater than 6% difference) are shown in Table 2.
Table 2: Adverse Reactions (%) in patients with PAH in Study 2 (incidence in Sildigra + Epoprostenol group at least 6% greater than Epoprostenol group)
Sildigra + Epoprostenol ^includes peripheral edemaSildigra Injection
Sildigra injection was studied in a 66-patient, placebo-controlled study in patients with PAH at doses targeting plasma concentrations between 10 and 500 ng/mL (up to 8 times the exposure of the recommended dose). Adverse events with Sildigra injection were similar to those seen with oral tablets.
The following adverse reactions have been identified during post-approval use of Sildigra (marketed for both PAH and erectile dysfunction). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
In postmarketing experience with Sildigra at doses indicated for erectile dysfunction, serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, pulmonary hemorrhage, and subarachnoid and intracerebral hemorrhages have been reported in temporal association with the use of the drug. Most, but not all, of these patients had preexisting cardiovascular risk factors. Many of these events were reported to occur during or shortly after sexual activity, and a few were reported to occur shortly after the use of Sildigra without sexual activity. Others were reported to have occurred hours to days after use concurrent with sexual activity. It is not possible to determine whether these events are related directly to Sildigra, to sexual activity, to the patient’s underlying cardiovascular disease, or to a combination of these or other factors.
Sildinafil Nervous system
Do not take Sildigra if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket). Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite (“poppers”). Taking Sildigra with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of Sildigra.
Do not take Sildigra more than once a day. Allow 24 hours to pass between doses. Do not take Sildigra while also taking Sildigra, unless your doctor tells you to.
Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.
Sildigra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking Sildigra, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old. It is not clear whether Sildigra is the actual cause of vision loss.
Stop using Sildigra and get emergency medical help if you have sudden vision loss.
Active ingredient matches for Sildigra:
Unit description / dosage (Manufacturer)Price, USD Tablet; Oral; Sildigra Citrate 100 mg Tablet; Oral; Sildigra Citrate 20 mg Tablet; Oral; Sildigra Citrate 25 mg Tablet; Oral; Sildigra Citrate 50 mg Sildigra citrate powder$ 24.38 Viagra 50 mg tablet$ 19.45 Viagra 100 mg tablet$ 19.45 Viagra 25 mg tablet$ 19.45 Revatio 20 mg tablet$ 17.50 Revatio 10 mg/12.5 ml vial$ 9.33 Brand Sildigra 100 mg – 8 Tablets$ 84.99 Brand Sildigra 100 mg – 12 Tablets$ 114.95 Brand Sildigra 100 mg – 16 Tablets$ 149.95 Brand Sildigra 50mg – 8 Tablets$ 69.95 Brand Sildigra 50mg – 12 Tablets$ 99.95 Brand Sildigra 50mg – 16 Tablets$ 119.95 Generic Sildigra 50 mg – 20 Tablets$ 37.99 Generic Sildigra 50 mg – 40 Tablets$ 59.95 Generic Sildigra 50 mg – 60 Tablets$ 84.95 Generic Sildigra 50 mg – 80 Tablets$ 104.95 Generic Sildigra 50mg – 100 Tablets$ 124.95 Generic Sildigra 50mg – 200 Tablets$ 184.95 Generic Sildigra 50mg – 300 Tablets$ 239.95 Generic Sildigra 100 mg – 20 Tablets$ 39.99 Generic Sildigra 100 mg – 40 Tablets$ 64.95 Generic Sildigra 100 mg – 60 Tablets$ 89.95 Generic Sildigra 100 mg – 80 Tablets$ 109.95 Generic Sildigra 100mg – 100 Tablets$ 129.95 Generic Sildigra 100mg – 200 Tablets$ 189.95 Generic Sildigra 100mg – 300 Tablets$ 259.95 Tablets; Oral; Sildigra Citrate 100 mg Tablets; Oral; Sildigra Citrate 20 mg Tablets; Oral; Sildigra Citrate 25 mg Tablets; Oral; Sildigra Citrate 50 mg Sildigra 50 MG TABLET 1 strip / 4 tablets each (Jan Aushadhi)$ 0.12 Sildigra tablet 100 mg (Sivem Pharmaceuticals Ulc (Canada)) Sildigra tablet 50.0 mg (Jamp Pharma Corporation (Canada)) Sildigra tablet 50 mg (Pharmascience Inc (Canada)) Sildigra tablet 25 mg (Pharmascience Inc (Canada)) Sildigra tablet 100.0 mg (Jamp Pharma Corporation (Canada)) Sildigra tablet, film coated 20 mg/1 (Greenstone LLC (US)) Sildigra tablet 25.0 mg (Jamp Pharma Corporation (Canada)) Sildigra tablet 20 mg/1 (A S Medication Solutions (US)) Sildigra injection, solution 10 mg/12.5mL (Auro Medics Pharma Llc (US))
List of Sildigra substitutes (brand and generic names):
Sildenafi Pfizer (Greece) Sildigra – 1 A Pharma (Germany) Sildigra 1A Farma (Sweden) Sildigra 1A Pharma (Austria, Netherlands, Poland) Sildigra 1A Pharma 100 mg (Austria) Sildigra 1A Pharma 25 mg (Austria) Sildigra 1A Pharma 50 mg (Austria) Sildigra 50mg Cheminter (Paraguay) Sildigra 50mg Millet (Paraguay) Sildigra : VI (Japan) Sildigra AbZ (Germany) Sildigra Accord (Estonia) Sildénafil Accord (France) Sildigra Actavis (Iceland, Latvia, Lithuania) Sildénafil Actavis (France) Sildigra Actavis 100mg (Austria, Israel) Sildigra Actavis 25mg (Israel) Sildigra Actavis 50mg (Austria) Sildigra Adair (Portugal) Sildigra Ajanta Pharma (Netherlands) Sildigra AL (Germany) Sildigra Amneal (Netherlands, Sweden) Sildigra AN PHT 20 (Australia) Sildigra Anglopharma (Colombia) Sildigra Apotex (Netherlands, Poland) Sildigra Apotex 100mg (Luxembourg) Sildigra Apotex 25mg (Luxembourg) Sildigra Apotex 50mg (Luxembourg) Sildigra Arpedex (Portugal) Sildigra Arrow (Poland) Sildénafil Arrow Lab (France) Sildigra Aspen (Denmark, Poland, Sweden) Sildigra Aurobindo (Germany) Sildigra Axapharm (Switzerland) Sildigra Axapharm 100mg (Switzerland) Sildigra Axapharm 25mg (Switzerland) Sildigra Axapharm 50mg (Switzerland) Sildigra Axxon (Poland) Sildigra Azevedos (Portugal) Sildigra Badinh Pharma (Vietnam) Sildigra Badinh Pharma 50 mg x 1 Blister x 4 Tablet See 1879 substitutes for Sildigra
- V-C Injection 500 mg (Ascorbic acid) 2 ml
- Lipotial 175 mg, 100 caps
- Fildena Super Active (Sildenafil Citrate) 100 mg shipped from UK
- Tramadol HCI (Centrafarm) Capsules 50 mg
- Linospan (Linezolid) 600 mg
- Nystatin 100 000 I.U (Vaginal)
- Sizopin (Clozapine) 25 mg
- Sizopin (Clozapine) 50 mg
- Viagra Uses
- Viagra (Generic) Sildenafil
25 mg – 30 tabs for $34.00, 50 mg – 30 tabs for $36.00, Sex Force 100 mg – 30 tabs for $38.00, 100 mg – 30 tabs for $38.00, Anaconda 120 mg – 30 tabs for $44.00, XL Plus 150 mg – 30 tabs for $49.00, Gold 200 mg – 30 tabs for $59.00, Professional 100 mg – 30 tabs for $79.00, Soft 100 mg – 30 tabs for $79.00