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Zopisign 10 mg (Zopiclone) Tablets


Price/Pill: $1.59
Generic Name: Zopiclone
Manufacturer: HAB Pharmaceuticals & Research Ltd

Zopisign, Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty falling asleep.

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What is Zopisign (Zopiclone)?

Zopisign belongs to the group of central nervous system (CNS) depressants (medicines that make you sleepy and less alert). Zopiclone is used to treat insomnia (trouble falling asleep), reduces daytime anxiety. Zopisign helps you fall asleep faster and sleep through the night with fewer interruptions in the deep sleep, helping people with sleeping problems. In general, when sleep medicines are used every night for a long time, they may lose their effectiveness.

Most of the time sleeping pills should be used for a shorter time, for a couple of days and not longer than 1 – 2 weeks

Zopiclone is available only with your doctor’s prescription.

Where to buy Zopiclone Online

Zopisign indications

An indication is a term used for the list of conditions or symptoms, or illnesses for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache, and body pains are the indications of paracetamol. A patient should be aware of medications used for common conditions because they can be taken over the counter in the pharmacy, meaning without prescription by the Physician.

In the treatment of transient, situational, and chronic insomnia.

In the case of situational transient insomnia, such as in shift workers, short-term treatment (3-7 days) with Zopiclone at the recommended dosage, will be sufficient to re-establish normal sleep.

In insomnia secondary to psychiatric disorders, including difficulty falling asleep, nocturnal awakenings, and early awakening.

Insomnia caused by more persisting life stress or psychological distress can demand longer treatment with Zopisign than for situational – transient insomnia. However, patients need to be periodically assessed for their insomnia, and treatment should not be prolonged if not necessary.

Uses of Zopiclone in details

There are specific as well as general uses of a drug or medicine. Medicine can prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after a few days, some drugs need to be continued for a prolonged period to benefit from it.

Zopiclone is used to treat insomnia (inability to sleep) in adults, including difficulty falling asleep, waking in the night or too early in the morning, severe sleep problems due to mood or mental health problems.

Zopiclone description

Novo-Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to Zopisign’s benzodiazepine pharmacological properties, it also has some barbiturate-like properties.

Zopisign dosage

The dose of Zopiclone: an average therapeutic dose of Zopisign Synthon Pharmaceuticals is 7.5 mg orally at night; in cases of severe insomnia, the dose can be increased up to 15 mg. In elderly patients, as well as abnormal liver function is used 3.75 mg.

Zopisign interactions

Zopisign also interacts with trimipramine and caffeine. Alcohol has an additive effect when combined with Zopiclone, enhancing the adverse effects, including the overdose potential of Zopisign significantly. A study assessing the impact of Zopisign on driving skills the next day found that the impairments on driving skills are double that of a social dose of alcohol. Zaleplon had no detrimental effects on driving skills the next day. Carbamazepine also has additive effects when combined with Zopisign, with both drugs enhancing each other’s side effects.

Erythromycin appears to increase the absorption rate of Zopisign and prolong the elimination half-life of Zopisign, leading to increased plasma levels and more pronounced effects. Itraconazole has a similar effect on Zopisign pharmacokinetics as erythromycin. The elderly may be particularly sensitive to the erythromycin and itraconazole drug interaction with Zopisign.

Temporary dosage reduction during combined therapy may be required, especially in the elderly. Rifampicin causes a very notable reduction in the half-life of Zopisign and peak plasma levels, which results in a large reduction in the hypnotic effect of Zopisign. Phenytoin and carbamazepine may also provoke similar interactions. Ketoconazole and sulfaphenazole interfere with the metabolism of Zopisign. Nefazodone impairs the metabolism of Zopisign, leading to increased Zopisign levels and marked next-day sedation. Contact your doctor or pharmacist to get more information

Do sleeping pills cause cancer?

A new study suggests that the 6% to 10% of Americans who use prescription sleep medications such as zolpidem (Ambien), temazepam (Restoril), eszopiclone (Lunesta) and zaleplon (Sonata) are more likely to develop cancer, and far more likely to die prematurely, than those who take no sleep aids.

Zopiclone side effects

The side effect most commonly seen in clinical trials is taste alteration or dysgeusia (bitter, metallic taste, usually fleeting in most users but can persist until the drugs half-life has expired). Palpitations may occur in the daytime following withdrawal from the drug after prolonged use (especially when taken for more than two weeks).

Zopisign induces amnesia type memory impairments similar to triazolam and Rohypnol. Impairment of driving skills with a resultant increased risk of road traffic accidents is probably the most important side effect. This side effect is not unique to Zopisign but also occurs with other hypnotic drugs.

More common reactions

Gastrointestinal: taste disturbances including bitter metallic taste, dry mouth. Nervous system: disruption of REM sleep, double vision, drowsiness, memory impairments, visuospatial impairments, dizziness, headaches, and fatigue. Unexpected mood changes have been noted, which, if experienced, should lead to the drug being withdrawn from the patient.

Less common reactions

Gastrointestinal: heartburn, constipation, diarrhea, nausea, coated tongue, bad breath, anorexia or increased appetite, vomiting, epigastric pains, dyspepsia, dehydration, parageusia.

Cardiovascular: palpitations in elderly patients.

Skin: urticaria, tingling in the arms and legs.

Miscellaneous: blurred vision, frequent micturition, mild to moderate increases in serum transaminases and/or alkaline phosphatase, and interstitial nephritis have been reported very rarely.

Reproductive: impotence, delayed ejaculation, anorgasmia in both women and men.

Nervous system: agitation, anxiety, loss of memory including retrograde and anterograde amnesia, confusion, dizziness, weakness, somnolence, asthenia, moderate to severe euphoria and/or dysphoria, feeling of drunkenness, depression, sleepwalking, coordination abnormality, hypotonia, speech disorder, hallucinations of various strengths, usually auditory and visual, behavioral disorders, aggression, tremor, rebound insomnia, nightmares, hypomania. Delirium can also occur but is a side effect mainly seen in the elderly.

Can zopiclone be abused?

Zopiclone has the potential for misuse and dosage escalation, drug abuse, and dependence on zopiclone. It is abused orally and sometimes intravenously and often combined with alcohol to achieve a combined sedative-hypnotic—alcohol euphoria. Patients abusing the drug are also at risk of dependence.

Zopiclone contraindications

Zopisign causes impaired driving skills, which are similar to benzodiazepines. Long term users of hypnotic drugs for sleep disorders only develop partial tolerance to adverse effects on driving. Even after 1-year of use, users of hypnotic drugs still show an increased motor vehicle accident rate.

Patients who drive motor vehicles should not take Zopiclone unless they stop driving due to a significantly increased risk of road traffic accidents in Zopisign users. Zopisign induces impairment of psychomotor function. Driving or operating machinery should be avoided after taking Zopiclone as effects can carry over to the next day, including impaired hand-eye coordination.

Patients with a history of substance abuse should not be prescribed Zopisign, as it has a very high potential for problematic drug misuse. Zopiclone is known to, in some cases, induce a state of amnesia, which is largely related (and not too dissimilar to sleep-walking).

This can extend to sleep-eating, sleep-talking (quite naturally), to dangerously sleep-driving.’ It is, therefore usually not used as an anti-anxiety drug (such as Benzodiazepines), as the patient may be liable to make inferior judgment decisions (as they are essentially mentally asleep) and attempt dangerous activities. – With absolutely no recollection at all of the events.

Does zopiclone help anxiety?

Zopiclone sleeping tablets reduces daytime anxiety; have a low frequency of rebound insomnia. Indicators of the propensity for dependence with a Hypno-sedative such as zopiclone are day time anxiety and rebound insomnia.

Does zopiclone sleeping pills calm you down?

Mental effects Zopiclone helps you sleep and makes you feel sleepy though users who manage to stay awake on it can feel drowsy and calm.

Zopiclone vs Zolpidem

Is Zolpidem the same as Zopiclone?

 Zolpidem was at least as effective as zopiclone, showed significantly less rebound on discontinuation and was better tolerated. Read more about Zolpidem, Stilnox, Ambien Sleeping Medication