Adapen Gel 0.1% (Adapalene Topical) 15 grams

Price/Tube: $29
Generic Name: Adapalene
Manufacturer: Various

Adapalene is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene works by affecting the growth of cells and decreasing swelling and inflammation.



Differin Generic Adapalene Topical

Why is this medication prescribed?

Adapalene is used to treat acne. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin.

How should this medicine be used?

Prescription adapalene comes as a gel, a solution (liquid), and a cream to apply to the skin. The solution comes in a glass bottle with an applicator and as individual pledgets (medicated wipes for one time use). Nonprescription (over the counter) adapalene comes as a gel to apply to the skin. Adapalene is usually applied once a day at bedtime. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Apply adapalene exactly as directed. Do not apply more or less of it or apply it more often than prescribed by your doctor or stated on the package. Applying more adapalene or applying adapalene more often than recommended will not speed up or improve results, but it may irritate your skin.

Adapalene controls acne but does not cure it. Your acne may get worse during the first few weeks of treatment, and it may take 8 to 12 weeks or longer before you feel the full benefit of adapalene. Pimples can take 6 to 8 weeks to form under the skin, and during the first weeks of your treatment, adapalene may bring these pimples to the skin surface. Continue to use adapalene even if your acne worsens or you do not see much improvement at first.

Do not apply adapalene to skin that is sunburned, broken, or covered with eczema (a skin disease). If you have any of these conditions, do not apply adapalene until your skin has healed.

Be careful not to get adapalene in your eyes, nose, or mouth. If you do get adapalene in your eyes, wash them with plenty of water and call your doctor. Your eyes may become irritated, swollen, or infected.

To use the cream, gel, or solution, follow these steps:

  1. Gently wash the affected skin with a mild soap or soapless cleanser and pat dry with a soft towel. Do not use harsh or abrasive cleansers, and do not scrub your skin vigorously. Ask your doctor or pharmacist to recommend a gentle cleanser.
  2. If you are using the gel or cream, use your fingers to spread a thin film of medication over the affected area. If you are using a pledget, remove it from the foil pouch and gently wipe the affected area. If you are using the glass bottle of solution, apply a thin layer to the affected area using the applicator provided. Adapalene should be applied to the entire affected area, not only to a single pimple or spot.
  3. You may feel a slight warmth or sting in the place where you applied adapalene. This feeling is normal and should go away by itself in a short time.
  4. If you used a pledget, discard it after use. Do not save it to use again.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking adapalene,

  • tell your doctor and pharmacist if you are allergic to adapalene or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or using. Be sure to mention all skin care products including soaps, cleansers, moisturizers, and cosmetics. Many skin care products can irritate your skin if you use them with adapalene. This is especially likely if you use products that are harsh, dry out the skin, or contain alcohol, spices, lime rind, sulfur, resorcinol, salicylic acid, glycolic acid, or alpha hydroxy acid. If you have been using these products, your doctor may want you to wait for your skin to return to normal before you begin using adapalene.
  • tell your doctor if you have or have ever had eczema or cancer.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using adapalene, call your doctor.
  • plan to avoid unnecessary or prolonged exposure to real and artificial sunlight (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen with an SPF of 15 or higher, especially if you sunburn easily. Also avoid prolonged exposure to cold or wind. Adapalene may make your skin sensitive to sunlight or extreme weather.
  • do not use hot wax to remove unwanted hair during your treatment with adapalene.
  • you should know that moisturizers may help relieve the dry skin or irritation that may occur with adapalene use,

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

What side effects can this medication cause?

Adapalene may cause side effects. The following symptoms are likely to affect your skin during the first 2-4 weeks of treatment. Tell your doctor if any of these symptoms are severe or do not go away:

  • redness
  • scaling
  • dryness
  • burning or stinging
  • itching

Medications that are similar to adapalene have caused tumors in laboratory animals who were given the medications and exposed to real or artificial sunlight. It is not known whether adapalene increases the risk of tumors in humans. Protect yourself from sunlight and sunlamps while taking adapalene, and talk to your doctor about the risks of taking this medication.

Adapalene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). If you are using a bottle of adapalene solution, be sure to store it upright.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of emergency/overdose

You should not swallow adapalene. If you swallow adapalene, call your local poison control center at 1-800-222-1222.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Differin®

Brand names of combination products

  • Epiduo® (containing Adapalene, Benzoyl Peroxide)

Adapalene Uses

What is Adapalene?

Adapalene (Adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Adapalene is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.

Adapalene may also be used for purposes not listed in this medication guide.

Adapalene indications

An indication is a term used for the list of conditions or symptoms or illnesses for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache, and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Adapalene Lotion is indicated for the topical treatment of acne vulgaris in patients 12 years and older.

How should I use Adapalene?

Use Adapalene cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Adapalene cream. Talk to your pharmacist if you have questions about this information.
  • Do not use other medicines on your skin without first discussing it with your doctor.
  • Adapalene Cream is for external use only. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Exposure of Adapalene cream to the eye may cause swelling, redness, and irritation.
  • Do not apply Adapalene cream to cuts, abrasions, eczematous skin, or sunburned skin.
  • Use Adapalene cream in the evening before bedtime unless directed otherwise by your doctor.
  • Before applying Adapalene cream, clean the area to be treated with mild soap or soapless cleanser and gently dry.
  • Apply a thin film of Adapalene cream to the affected and surrounding area. Rub in gently. Wash your hands immediately after using Adapalene cream.
  • A mild sensation of warmth or slight stinging may occur shortly after using Adapalene cream.
  • If you miss a dose of Adapalene cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Adapalene cream.

Uses of Adapalene in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

How to use Adapalene topical

Wash your hands before applying this medication. Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication in a thin layer, usually once daily at bedtime, or as directed by your doctor. A gauze pad or cotton swab can be used to apply the solution.

Use this medication on the skin only. Do not apply to the inner lip area or inside the nose/mouth. Do not apply to cut, scraped, sunburned, or eczema-affected skin.

Avoid getting this medication in your eyes. If this medication gets into your eyes, flush with large amounts of water. Call your doctor if eye irritation develops. Wash your hands after using the medication to avoid accidentally getting it in your eyes.

During the first few weeks of using adapalene, your acne might appear worse because the medication is working on pimples forming inside the skin. It may take up to 8-12 weeks to notice results from this medication.

Use it regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not use a larger amount or use it more frequently than recommended. Your skin will not improve any faster, and it will increase the risk of developing redness, peeling and pain.

This medication is available in different strengths and forms (e.g., gel, cream, solution). The best type of medication for you to use will depend on the condition of your skin and your response to therapy. Inform your doctor if your condition persists or worsens.

Adapalene description

Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Adapalene in some countries, and Adapalene in India. [Wikipedia]

Adapalene dosage

Usual Adult Dose for Acne



Adapalene should not be applied to the skin with cuts, abrasions, eczema, or sunburn.

Patients should minimize exposure to sunlight, including sunlamps, and use sunscreens and other protection whenever prolonged exposure is unavoidable. Therapy should be discontinued if sunburn develops, and not resumed until the skin fully recovers. Patients may also have a heightened susceptibility to irritation due to weather extremes (wind or cold).

Adapalene may cause erythema, dryness, scaling, burning, and itching, which usually begin the first 2 to 4 weeks of therapy but diminish with continued use. Patients who develop excessive irritation should use the medication less frequently, interrupt treatment briefly, or discontinue use totally.

Adapalene therapy may render the skin more vulnerable to the irritating effects of astringents, abrasive soaps, skin cleansers, and other facial chemicals and cosmetics that contain alcohol or have a strong drying effect. Concomitant use of these agents with Adapalene should be approached with caution. Products containing alpha hydroxy or glycolic acids should be avoided.

Adapalene should not be used around the eyes, mouth, angles of the nose, mucous membranes, or on the cut, abraded, or eczematous skin. Contact with the eye may cause an ocular reaction such as swelling, conjunctivitis, and irritation.

Wax epilation should not be performed on Adapalene-treated skin.

Safety and effectiveness in pediatric patients under the age of 12 years have not been established.


Other Comments

Initially, an apparent exacerbation of acne may appear within the first few weeks of treatment due to the action of Adapalene topical on previously unseen lesions. Therapeutic results are typically noticed after 8 to 12 weeks of treatment.

Adapalene interactions

As Adapalene® (Adapalene gel) Gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with Adapalene® (Adapalene gel) Gel. If these preparations have been used, it is advisable not to start therapy with Adapalene® (Adapalene gel) Gel until the effects of such preparations in the skin have subsided.

Adapalene side effects

In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used Adapalene Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with Adapalene Cream from the controlled clinical studies is provided in the following table:

Incidence of Local Cutaneous Irritations with Adapalene Cream

from Controlled Clinical Studies (N=285)

None4% (12) <1% (2)

Other reported local cutaneous adverse events in patients who used Adapalene Cream once daily included: sunburn (2%), skin discomfort-burning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with Adapalene Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.

Adapalene contraindications

Avoid getting this medication in your eyes, in the creases of your nose, or on your lips. If it does get into any of these areas, wash with water. Do not use Adapalene topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Adapalene topical.

Do not use skin products that contain alpha hydroxy or glycolic acid while you are also using Adapalene topical.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medication skin products unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Adapalene topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Active ingredient matches for Adapalene:


Unit description / dosage (Manufacturer)Price, USD Differin 0.1% Cream 45 gm Tube$ 227.13 Differin 0.1% Gel 45 gm Tube$ 227.13 Differin 0.3% Gel 45 gm Tube$ 219.65 Differin 0.1% cream$ 4.85 Adapalene 0.1 % x 1 g Adapalene 0.1 % x 5 g Adapalene 0.1 % x 15 g Adapalene 0.1 % x 30 g Adapalene 0.1 % x 40 g Adapalene 0.1 % x 200 g Gel; Topical; Adapalene 0.1% Cream; Topical; Adapalene 0.1% Adapalene lotion .1 g/100mL (Owen Laboratories, Inc. (US)) Adapalene cream .1 g/100g (Perrigo New York Inc (US)) Adapalene gel 3 mg/g (Owen Laboratories, Inc. (US)) Adapalene gel 1 mg/g (Taro Pharmaceuticals U.S.A., Inc. (US)) Adapalene gel 45 g/g (Pru Gen, Inc. (US)) Adapalene cream 1 mg/g (E. Fougera & Co. a division of Fougera Pharmaceuticals Inc. (US)) Adapalene swab 1 mg/mL (Call Inc. (Dba Rochester Pharmaceuticals, US))

List of Adapalene substitutes (brand and generic names):

Adapalen Adapalene Borg 0.1% (Egypt) Adapalene Cream Adapalene Fougera (United States) Adapalene Glenmark (United States) Adapalene Lotion Adapalene Pads Adapalene Pliva (United States) Adapalene Sinphar (Taiwan) Adapalene Solution Adapalène Teva 0.1% (France) Adapalène Zentiva 0.1% (France) ADAPALENE-ALHAVI Adapaleno Gel; Topical; Adapalene 1% Adapaleno Biosintetica (Brazil) Adapaleno EMS (Brazil) Adapaleno Gen.Germed (Brazil) Adapaleno Lafedar (Argentina) Adapaleno Medley (Brazil) AdapalГЁne Teva (France) AdapalГЁne Winthrop (France) Adapel (Bangladesh) Adapen (India) Adapen 0.001 Gel / 15gm (Intas Laboratories Pvt Ltd)$ 1.19 0.1 % x 15g (Intas Laboratories Pvt Ltd)$ 1.19 Gel; Topical; Adapalene 0.1% (Intas Laboratories Pvt Ltd) Adapen Skin 15 gm Gel (Intas Laboratories Pvt Ltd)$ 1.33 ADAPEN 0.1% W/W GEL 1 tube / 15 GM gel each (Intas Laboratories Pvt Ltd)$ 1.78 ADAPEN topical gel 0.1 % x 15g (Intas Laboratories Pvt Ltd)$ 1.19 Adapen 0.1% w/w Gel (Intas Laboratories Pvt Ltd)$ 1.94 Adaple (India) Gel; Topical; Adapalene 0.1% (Wallace Pharmaceuticals Ltd.) Adaple Skin 15 gm Gel (Wallace Pharmaceuticals Ltd.)$ 1.27 ADAPLE GEL (India) ADAPLE GEL Cream/ Gel/ Ointment / 0.1/ % / 15gm units (Wallace)$ 1.27 Adaple gel 0.1% w/w Gel / 15g (Wallace)$ 1.27 0.1 % w/w x 15g (Wallace)$ 1.27 ADAPLE GEL topical gel 0.1 % w/w x 15g (Wallace)$ 1.27 Adaple gel 0.1% w/w Gel / 15g (Wallace)$ 1.27 Adapne (Argentina) ADARET (India) ADARET Cream/ Gel/ Ointment / 0.1/ % / 15gm units (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 1.19 0.1 % w/w x 15g (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 1.38 Adaret 0.1%w/w GEL / 15g (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 1.38 Gel; Topical; Adapalene 0.1% (Cosme Healthcare (CFL Pharmaceuticals Ltd)) Adaret Skin 15 gm Gel (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 1.51 See 443 substitutes for Adapalene


  1. DailyMed. “ADAPALENE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).”. https://dailymed.nlm.nih.gov/dailyme…
  2. PubChem. “ADAPALENE”. https://pubchem.ncbi.nlm.nih.gov/com…
  3. DrugBank. “ADAPALENE”. http://www.drugbank.ca/drugs/DB00210

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